Plasma insulin was found to be correlated with higher inflammatory tone in perigonadal (r = 0.64, p < 0.001) and mesenteric fat depots (r = 0.56, p < 0.001), and microvesicular steatosis (r = 0.56, p < 0.001) in male mice further supporting the use of male mice as a model for NAFLD/NASH [25,27,62]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.