If this effect of ICW on muscle cells were confirmed, it would represent a huge advance in our understanding of the pathogenesis of sarcopenia, dynapenia and frailty, since insulin, along with other hormones such as insulin-like growth factor 1 (IGF-1), are a requirement for muscle growth, muscle regeneration and protein synthesis through the mTORC1 pathway [86]. This evidence concerns the gene IGF1 and sarcopenia.