More specifically, autophagy is central in eliminating the substrates that will ultimately give rise to amyloids and fibrils in several neurodegenerative diseases (Aβ peptide and tau protein in AD [64,65], alpha-synuclein in PD [66], mutated huntingtin in Huntington disease [67], and superoxide dismutase 1 (SOD1) in ALS [68]). This evidence concerns the gene SOD1 and neurodegenerative disease.