MYC and osteosarcoma: The consequences of Myc SUMOylation are however conflicting since one study suggests that it facilitates its degradation via the recruitment of the RNF4 StUbL, in osteosarcoma epithelial cell context [91] and another that Myc SUMOylation leads to its stabilization and enhances its transcriptional activity, in particular by increasing its interaction with its transcriptional partner Max [92].