AKT interacts with various other signaling pathways, most notably MAPK (mitogen-activated protein kinases) at the TKR (Tyrosine Lysine Arginine) residue via TKR phosphorylation, leading to RAS-GTP (rat sarcoma- guanosine triphosphate) recruitment (through adapter proteins Grb-2 and SOS (son of sevenless)). The gene discussed is TKTL1; the disease is sarcoma.