In contrast, some studies have shown that polymorphisms located in the KDR gene are associated with the risk of several human diseases such as chronic myeloid leukemia, breast cancer, glioblastoma, colorectal cancer, cardiovascular disease, or type 2 diabetes [31,39,40,41,42,43,44,45,46]. This evidence concerns the gene KDR and chronic myelogenous leukemia, BCR-ABL1 positive.