Some previous studies have shown that LRP5 A1330V, LRP5 V667 M, RAD51B rs911263, TLR10 I473T, IL-6 rs4453032 SNPs were associated with erosion in RA patients [24,25,26,27]; LRP5 V667 M, NLRP3 rs10754558 and CARD8 rs2043211 polymorphisms were associated with Health Assessment Questionnaire (HAQ) scores [24,28]; and FLT-1 rs7324510 and AFF3 rs11676922 SNPs were associated with VAS score, DAS-28 score, and ExRA presence [29,30]. Here, LRP5 is linked to rheumatoid arthritis.