Various mouse models of AD (APP/PS1, mouse models of Aβ deposition, carrying mutations in APP and/or presenilin 1, and Tg4510, mouse model as a model of tau deposition) under KD (low carbohydrate, MCT-rich diet) had elevated KBs level and reduced glucose levels in the bloodstream [11,12]. Here, PSEN1 is linked to Alzheimer disease.