Recently, Jesionek-Kupnicka and co-workers validated a panel of five miRNAs—miR-21, miR-125b, miR-34a, miR-181d, and miR-648—strictly involved in MGMT and TP53 alterations, therefore responsible for the progression of glioblastoma [132]. The gene discussed is TP53; the disease is glioblastoma.