IDH1 and central nervous system cancer: Finally, some of the main biomarkers identified in extracellular vesicles and linked with GDM exosomes is the glioma-specific receptor of epidermal growth factor (EGFRvIII), which is a piece of mRNA with the receptor (found in serum), miR21 which is an essential miRNA for GBM diagnosis (found in serum), and the mutant IDH1 mRNA found in CSF [173,174,175,176].