When breaking up cardiovascular events into its two components, subjects with SELENOP deficiency were at significantly increased risk of both coronary artery disease (490 events) [1.27 (1.03–1.57) (p = 0.025)] and stroke (305 events) [1.57 (1.21–2.02) (p = 0.001)]. This evidence concerns the gene SELENOP and hyperinsulinemic hypoglycemia, familial, 4.