SELENOP and hyperinsulinemic hypoglycemia, familial, 4: Interestingly, among non-smokers SELENOP deficiency was significantly associated with all-cause mortality [1.56 (1.33–1.82) (p = 2.9 × 10−8)], cardiovascular mortality [1.88 (1.44–2.45) (p = 3.0 × 10−6)] and first cardiovascular event [1.47 (1.21–1.79) (p = 1.1 × 10−4)], whereas the association between SELENOP deficiency and the three main endpoints was weaker or non-significant among smokers (Table 3).