In multivariate adjusted analyses, subjects with SELENOP deficiency as compared to subjects with normal SELENOP plasma concentration had a hazard ratio (95% confidence interval) of 1.51 (1.32–1.72) (p = 1.2 × 10−9) for all- cause mortality; 1.61 (1.32–2.09) (p = 1.7 × 10−5) for cardiovascular mortality, and 1.43 (1.21–1.69) (p = 2.7 × 10−5) for first cardiovascular event. The gene discussed is SELENOP; the disease is hyperinsulinemic hypoglycemia, familial, 4.