PTEN and small cell lung carcinoma: Whole genome sequencing in plasma cell free DNA of 24 SCLC patients detected PTEN deletion in 29% (7/24), while blood samples from 99 SCLC patients subjected to targeted mutational analysis on codons 5 (p.R130G), 6 (p.R173C) and 8 (p.T319fs*1) of PTEN, resulted negative for each of the specified [81,82].