Interestingly, both PTEN and PTEN-L, an alternative less abundant transcriptional variant, 173 amino acids longer, were found to be secreted in the extracellular environment exerting their tumor suppressor properties into the recipient cells in a cell autonomous manner, a finding that might imply pharmaceutical utility for PTEN delivery (Figure 1) [12,13,14]. This evidence concerns the gene PTEN and neoplasm.