For example, when patched on the acute rat MI model, the cardiac dECM generated by seeding a mixture of human iPSC-derived CMs and iPSC-derived CD90+ cells, has shown to reduce infract size, increase wall thickness and promote vascularization as indicated by positive staining of vWF and α-SMA, leading to improve the heart function compared to the control group [26]. This evidence concerns the gene ACTA1 and myocardial infarction.