High cholesterol level impacts β-amyloid formation in the brain (Reed et al., 2014); abnormal insulin function, a key factor of T2D and related disorders (Basu et al., 2005), increases the risk for AD (Ronnemaa et al., 2008); cardiovascular risk factors such as high cholesterol and hypertension are common to T2D and AD (Kivipelto et al., 2005). This evidence concerns the gene INS and Alzheimer disease.