ISL1 and Alzheimer disease: Among the comorbid genes, 8—ALOX5, APP, BIN1, CHGB, VWF, NEFL, LETMD1, CELF1- were identified as known AD target genes (Bertram et al., 2007; Sun et al., 2012; Bai et al., 2016) and 14—TCF7L2, APOA1, VWF, CDKN2B, CAT, ITGB2, ISL1, POLD3, APP, NFKBIB, GNA12, DEDD, LDLR, PRKAB1- as known T2D target genes (Dai et al., 2013), APP and VWF are known targets of both diseases (Table 8).