The major criteria for classical or malignancy-associated Sweet’s syndrome include 1) an abrupt onset of painful erythematous plaques or nodules, and 2) histology of skin lesions showing a neutrophilic infiltrate in the absence of infection or vasculitis.18 Minor criteria include 1) fever greater than 38oC, 2) an association with malignancy, inflammatory or infectious disease, or vaccination, and 3) elevation of inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white cell count or percentage of neutrophils. This evidence concerns the gene CRP and sweet syndrome.