GSTM1 and restless legs syndrome: Some studies have shown that low serum iron levels may be a risk factor associated with the development of EPSEs – especially akathisia in schizophrenia patients treated with antipsychotics.26 Furthermore, iron deficiency has been shown to aggravate the symptoms of restless leg syndrome.27 However, we found no significant association between EPSEs and ferritin or Hb levels.