Molecular technique is the recommended diagnostic method for confirmation of KS [15] and it is on this basis that this study was designed to detect K1 and K15 (P) genes of Human herpes virus-8 associated Kaposi's sarcoma among HIV-1 and Acquired Immunodeficiency Disease Syndrome (AIDS) patients using nested polymerase chain reaction (PCR) technique. This evidence concerns the gene KRT15 and AIDS.