While andrographolide enhanced the expression of Bax, caspase-3, and caspase-9, it down-regulated that of Bcl-2, leading to apoptosis in melanoma B16F-10 cells (Pratheeshkumar et al., 2012), and it promoted apoptosis in pancreatic cancer cells via inhibition of STAT3 and Akt activation (Bao et al., 2013). This evidence concerns the gene CASP3 and melanoma.