In addition to the overall weaker inflammatory infiltration (most likely associated with much lower antigen load), H99-α shifted the immune response balance toward Th1, which is evidenced by (1) condensed immune cells infiltration around infection sites with restrained fungal dissemination; (2) altered inflammatory infiltration phenotype from eosinophil and myeloid cell-dominant toward lymphocyte-dominant pattern; and (3) the improved Th1/Th2 cytokine ratio. Here, NELFCD is linked to infection.