Decreased expression of HOTAIRM1/HOXA1 has been observed in the MDSCs of patients with lung cancerNegative association between the expression of HOTAIRM1/HOXA1 and presence of MDSCs, as well as Arg1 levels has been observed in patients with lung cancerPositive association between expression of HOTAIRM1/HOXA1 and proportions of Th1/cytotoxic T cells in patients with lung cancer. The gene discussed is HOXA1; the disease is lung cancer.