Limb-girdle muscular dystrophy (MD) type 2B (LGMD2B) and Miyoshi myopathy are forms of MD caused by mutations in the dysferlin gene[1–3], a calcium-dependent sarcolemma repair and vesicle trafficking protein [[4,5] and reviewed in [6]]. The gene discussed is DYSF; the disease is autosomal recessive limb-girdle muscular dystrophy type 2B.