DYSF and neuromuscular disease caused by qualitative or quantitative defects of dysferlin: For this purpose, the effect of chronic losartan treatment (9 mo) on muscle wasting was evaluated in two mouse models of diet-accelerated dysferlinopathy; 1) dysferlin-null mice fed a control diet, and 2) dysferlin-null mice fed a high-fat Western diet (HFD), previously shown to exacerbate LGMD2B severity [9,18].