In three families, phenolyzer prioritized genes that are associated with hereditary neuropathies (family A, KARS, Charcot-Marie-Tooth disease B (OMIM 613641); family B, KIF5A, spastic paraplegia 10 with or without peripheral neuropathy (OMIM 604187); and family F, NTRK1, hereditary sensory and autonomic neuropathy IV (OMIM 256800). This evidence concerns the gene KARS1 and Spastic paraplegia.