These results suggest that the suppression effect of hTERT transcription by introduction of ZCCHC10 and PITX1 involved in senescence and apoptosis, however these introduction of tumor suppression effects may be influenced balances of hTERT canonical and non-canonical function that telomere shortening, restoration of tRNA level, beta-catenin and NF-kappa B signaling pathways [10–12]. The gene discussed is PITX1; the disease is neoplasm.