CD274 and cutaneous melanoma: Although not statistically significant, PD-L1 expression and higher TMB were associated with higher ORR, consistent with previous reports in cutaneous melanomas.38,39 Notably, PD-L1–positive patients had a statistically significant PFS advantage compared with PD-L1–negative patients (hazard ratio, 0.38; 95% CI, 0.14 to 1.00; P = .049).