Grade 3 TRAEs included proteinuria (n = 3), hypertension (n = 3), neutropenia (n = 3), ALT elevation (n = 2), weight loss (n = 2), diarrhea (n = 1), creatine kinase elevation (n = 1), AST elevation (n = 1), lipase elevation (n = 1), leukopenia (n = 1), anemia (n = 1), γ-glutamyl transferase elevation (n = 1), blood creatinine elevation (n = 1), hyponatremia (n = 1), and esophageal fistula (n = 1). The gene discussed is GPT; the disease is hypertensive disorder.