In recent years, a host response of simultaneous pro‐ and anti‐inflammatory nature has been recognized to prevail during sepsis, and a balanced response is now considered to produce a more favorable disease outcome.23 It is of interest to note that caspase‐1 is also responsible for the maturation of the anti‐inflammatory cytokine IL‐37, which binds to IL‐18R.33 Future studies should determine the levels of this cytokine in parallel to, for example, IL‐1β and IL‐18. This evidence concerns the gene IL1B and Sepsis.