Previous studies focusing on S. aureus‐mediated NLRP3 inflammasome activation have mainly been performed in vitro or in murine models.6, 7, 16, 17, 18, 19 This study investigated the activation of the caspase‐1 inflammasome during the acute phase of infection, by repeated measurement over time, in a cohort of patients with SAB, all with methicillin‐sensitive S. aureus. Here, NLRP3 is linked to infection.