IL1B and infection: In addition, expression of the NLRP3 protein and other inflammasome components has been demonstrated in neutrophils,28 and neutrophil‐mediated IL‐1β has been suggested to play a major role in the innate immune response.29 Increased caspase‐1 activity in neutrophils has also been demonstrated during Helicobacter pylori infection.9 These studies, taken together with our data showing a significant caspase‐1 activity in neutrophils, highlight the importance of neutrophils in NLR signaling during infections such as SAB.