We performed an interphase FISH analysis to sort for main chromosome translocations involving C-MYC, BCL2, and BCL6. Our results demonstrated a lower rearrangement rate in the EBV+ DLBCL cohort compared with EBV-negative DLBCL with 10 vs. 19.2%, 0 vs. 7.7%, 15 vs. 26.9%, of the C-MYC, BCL2, and BCL6 loci, respectively. Here, BCL6 is linked to diffuse large B-cell lymphoma.