Here, we found that high mRNA expression of PRDX4/6 were significantly associated with poor OS of BrCa patients and high mRNA expression of PRDX1/2/4/5/6 were significantly associated with shorter RFS of BrCa patients, while high mRNA expression of PRDX3 was notably related to favorable OS and DFS, which suggests the tumor suppressor role of PRDX3 in BrCa. Here, PRDX3 is linked to invasive breast carcinoma.