As shown in Fig. 4 and Fig. 5, high mRNA expression of PRDX4 (HR = 1.54, 95% CI: 1.24–1.91, P < 0.001), and PRDX6 (HR = 1.26, 95% CI: 1.02–1.56, P = 0.033) were significantly associated with poor overall survival (OS) of BrCa patients, while high mRNA expression of PRDX3 was notably related to favorable OS of BrCa patients (HR = 0.74, 95% CI: 0.59–0.91, P = 0.005). This evidence concerns the gene PRDX4 and invasive breast carcinoma.