Pang et al. (2014) validated that downregulated miR-486-5p and upregulated eIF4E led to the overexpression of Pim-1 kinase, a critical survival signaling factor in NSCLC. Peng et al. (2013) recently reported that miR-486 directly targeted insulin growth factor signaling and functioned as a potent tumor suppressor of lung cancer both in vitro and in vivo. The gene discussed is EIF4E; the disease is lung cancer.