The high expression of CD91/LRP1 in the placenta during pregnancy and the activity of the heme-hemopexin clearance system in the brain after subarachnoid hemorrhage suggest that various forms of stress, where there are changes in vascular permeability, organs other than the liver may see the heme-hemopexin complex entering tissue parenchyma. This evidence concerns the gene LRP1 and subarachnoid hemorrhage.