Patients with severe psoriasis have increased levels of inflammatory cytokines, CRP, fibrinogen, α2 macroglobulin or PAI-1 (plasminogen activator inhibitor-1) in the blood (79–81), they show transcriptomic, proteomic and metabolomic abnormalities (82) and there are connections with chronic stress (83) and biophysical properties of the skin (84). The gene discussed is SERPINE1; the disease is psoriasis.