TNFα-induced protein 3 (TNFAIP3), which negatively regulates NF-κB signaling, is another gene thought to be involved in rheumatoid arthritis and psoriasis alike, but also in Crohn's disease, celiac disease, and systemic lupus erythematosus (155, 156). This evidence concerns the gene NFKB1 and rheumatoid arthritis.