In vitro infections of RAW264.7 cells with ΔsseK123 S. Typhimurium showed similar levels of caspase-3/-7 activation when compared to WT infection, but resulted in higher levels of MLKL phosphorylation, indicating that SseK1 and SseK3 may specifically inhibit necroptotic cell death (83). Here, CASP3 is linked to infection.