Sometimes TILs, specifically cytotoxic CD8+ memory T cells and CD4+ T helper 1 (Th1), which are normally antigen “experienced,” kill tumor cells (29), and the presence of lymphocytes in tumors is often associated with a better prognosis during immunotherapy treatment, including the adoptive transfer of naturally- TIL or genetically-engineered T cells and the use of immune-checkpoint inhibitors (26, 30). This evidence concerns the gene CD4 and neoplasm.