SIRT1 is involved in (i) Th and Treg cell differentiation (238, 241); (ii) SIRT1 signals in DCs can repress PPARγ activity and promote T helper 2 (Th2) cell responses in airway allergy through metabolism-independent manners (242); (iii) SIRT1 interacts with c- Jun and inhibits CD4 T cells to mediate T cell tolerance (243); (iv) SIRT1 regulates CD8 T-cell differentiation interacting with basic leucine zipper transcription factor ATF-like (BATF) and regulating both epigenetic remodeling and energy metabolism of T cells (244). Here, SIRT1 is linked to allergic respiratory disease.