For example, NAMPT has a role in the induction of an immunosuppressive and tumor-promoting microenvironment in chronic lymphocytic leukemia, where eNAMPT is important for the differentiation of monocytes toward tumor-supporting immunosuppresive M2 macrophage, promoting their differentiation, and polarization in tumor-supportive cells including TAMs (130). This evidence concerns the gene NAMPT and neoplasm.