GNRH1 and metabolic disease: In the context of Hypo-H, few studies exist in organic, genetic or idiopathic forms of Hypo-H, focused on metabolic profile and on the potential independent role of testosterone deficiency in the development of metabolic disorders; nevertheless, hypogonadism due to deficient production, secretion, or action of GnRH, as well as pharmacologically-induced hypogonadism for androgen deprivation therapy (ADT), might represent suitable clinical models of Hypo-H, with available evidence of testosterone deficiency-induced metabolic disorders.