PLOD1 and hypogonadism: A cross-sectional cohort study on 355 men with T2-DM confirmed a high prevalence of Hypo-H in T2-DM patients, defined as low TT and FT levels, and low or inappropriately normal LH levels; moreover, by including the assessment of prevalence of symptoms related to hypogonadism, a prevalence of 17% and 14% of hypogonadism was found, when considering low TT or low FT, respectively (28).