Indeed, in obese men, SHBG levels may be low, and low TT and/or FT levels have been associated with low or inappropriately normal gonadotropins levels; therefore, a condition defined as male obesity-related Hypo-H might be diagnosed in obese patients presenting with this impairment of HPT axis, along with signs and symptoms of hypogonadism, in absence of an organic impairment of the axis, and recognized causes of hypogonadism (41). Here, SHBG is linked to hypogonadism.