Moreover, a population based, prospective cohort study on 1,896 men with mean age of 52 years demonstrated that TT, FT, and SHBG levels were significantly lower in men with MetS compared to men without MetS, and that men in the lowest tertile for FT levels were more likely to have MetS, after adjusting for age and BMI (16). Here, SHBG is linked to metabolic syndrome.