Lastly, consistently with different studies in non-diabetic normal or overweight men with or without MetS (70, 71), calculated FT levels were negatively correlated with insulin levels, HOMA-IR and VAT, also in a cross-sectional cohort study on men with T2-DM, further supporting the hypothesis that IR reduces circulating testosterone levels, and that reduced circulating testosterone, in turn, contributes to increase IR (66). The gene discussed is INS; the disease is metabolic syndrome.