From WB result of retinal tissues from different age of RCS and normal control rats, we can find the expressions of pJAK2, pSTAT3, JAK2, and STAT3 were all up-regulated during retinal degeneration in RCS rats (n = 3 per group, Supplementary Figure S1) (JAK2: P30: 1.11 ± 0.09 fold; P60: 2.04 ± 0.13 fold; P90: 2.26 ± 0.12 fold; n = 3 per group; p < 0.01 for P60 and P90 RCS vs. control; STAT3: P30: 1.13 ± 0.12-fold; P60: 1.53 ± 0.05-fold; P90: 1.72 ± 0.11-fold; n = 3 per group; p < 0.01 for P60 and P90 RCS vs. control) (Figures 3A–C). The gene discussed is JAK2; the disease is retinal degeneration.