The results shown in Figure 3D reveal that retinal degeneration induced the high expression of pro-inflammatory factors such as TNF-α, IL-6, ICAM-1, and MCP-1 in a time-dependent manner, which is indicative that microglia/macrophages were activated with “classically” phenotype (Qin et al., 2016). This evidence concerns the gene IL6 and retinal degeneration.