PDE6B and retinal degeneration: In our research, in vivo experiments demonstrated that the JAK2/STAT3 pathway became activated during degenerative period which was the same as research on retinal degeneration has shown that JAK2 and STAT3 proteins are involved in photoreceptor apoptosis, especially in rd1 mice model (Samardzija et al., 2006; Lange et al., 2010).