Since SOX9 is known as a TF (Shi et al., 2018) and former report has determined that SOX9 is responsible for the upregulation of lncRNA MALAT1 in lung cancer (Chen et al., 2017), we asked whether SOX9 could transcriptionally regulate SOX9‐AS1 expression in HCC. This evidence concerns the gene SOX9 and hepatocellular carcinoma.