MMP13 and neoplasm: miRNAs always serve as fine‐tuning regulators such as onco‐miRNAs or tumour‐suppressor miRNAs for diverse biological processes, which is mainly dependent on its downstream genes.9 Previous studies showed that miR‐9 was up‐regulated in late‐stage OA cartilage and directly targeted MMP‐13.10 Besides, Okuhara et al reported that miR‐146a could also directly target MMP‐13 and was significantly higher during the early stages of OA than during the later stages.11 Based on latest research, miR‐127‐5p regulated MMP‐13 expression and IL‐1β‐induced catabolic response in human chondrocytes.12