The specific role TGF‐β plays during aneurysm formation in MFS murine models remains complicated, although most animal studies support a pathologic function through aortic wall remodelling in two different Marfan mouse models (Fbn1mgR/mgR and Fbn1C1039G/+).5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 32, 33 Identifying key components within the molecular pathway(s) that lead to aneurysm formation may translate into innovative medical therapies directed at preventing or slowing aneurysm growth 33, 34. The gene discussed is TGFB1; the disease is aneurysm.