In their ROC analysis, the aAnxV IgG and the aPE IgG were the best biomarker discriminating the seronegative patients from healthy controls, with AUC >0.8,9 suggesting the usefulness of the non‐conventional aPLs when evaluating suspected APS patients in the absence of LA, aCL, or aβ2‐GPI. The gene discussed is GPI; the disease is autoimmune polyendocrinopathy.