Studies have found that CD8+CD122+ Tregs are fairly potent in immunosuppression.17, 18, 19 In addition, since CD28 is a major costimulatory receptor, CD8+CD28− T cells appear to negatively impact immune responses,20 and fewer CD8+ T cells expressed CD28 in SLE patients.21 This evidence concerns the gene CD8A and systemic lupus erythematosus.