Unlike CD4+Foxp3+ Tregs, these cells suppressed T cell responses regardless of Foxp3 expression, and they also played a role in the spontaneous liver tolerance and autoimmunosuppression of stimulatory graft-versus-host disease (GVHD) with a lupus-like syndrome.24, 25, 26, 27. This evidence concerns the gene CD4 and graft versus host disease.