CRP and alkaline phosphatase measurement: 1993; Pápa et al. 2011; Mansfield 2012a). The potential for the development of severe complications and the associated high mortality implies that clinicians should attempt to determine whether a case is mild or severe, using an appropriate method, and institute hospitalization and intensive care immediately if it is considered to be severe (Sato et al. 2017). Various studies have identified biomarkers of AP such as serum paraoxonase 1 activity and C-reactive protein (CRP) (Tvarijonaviciute et al. 2015; Sato et al. 2017).