It is associated with chronic inflammation caused by radiation exposure (phototype I-II), chronic wounds (burn scars, ulcers, epidermolysis, fistulas), chemical carcinogens, immunosuppression, several genetic diseases, (that involve Bax immunoreactivity [psoriasis vulgaris]) and chronic infection, such as human papillomavirus infection [7,8]. Here, BAX is linked to human papilloma virus infection.