KLF5 and Barrett esophagus: KLF5 expression in BE exhibited a strikingly different pattern than in EAC, both in vitro and in vivo. The low levels of KLF5 expression we observed in BE cells and tissues may imply that BE cells and tissues resemble differentiated intestinal cells, which are known to have low KLF5 expression; conversely, higher KLF5 expression in EAC cells and tissues may reflect their similarity to less-differentiated basal intestinal epithelial cells, which express high KLF5 levels [23], [27].