ADAMTS9 and nonpapillary renal cell carcinoma: Since ADAMTS9-AS2 inhibited miR-27a-3p activity, and miR-27a-3p inhibited FOXO1 expression, we hypothesized that the inhibition of ccRCC cell proliferation and chemoresistance induced by ADAMTS9-AS2 overexpression may be attributed to the decreased expression of miR-27a-3p and consequent increased expression of FOXO1.