Consistently, we observed that the colony formation of ccRCC cells was significantly inhibited in 786-O and caki-1 cells with ADAMTS9-AS2 overexpression (Figure 4E, P<0.01) or miR-27a-3p knockdown (Figure 4F, P<0.01), according to the crystal violet staining. Here, ADAMTS9 is linked to nonpapillary renal cell carcinoma.