ADAMTS9-AS2 overexpression MUT had no significant facilitating effect on sensitivity of ccRCC cells to both 5-Fu and Cisplatin treatment, whereas the simultaneous miR-27a-3p overexpression decreased the sensitivity of ccRCC cells to both 5-Fu and Cisplatin treatment (Figure 7E, P<0.01). The gene discussed is ADAMTS9; the disease is nonpapillary renal cell carcinoma.