To further investigate the in vivo function of GGCT in oncogenic Ras-induced cancer formation, we crossed GGCT−/− mouse with (Lox-Stop-Lox) LSL- Kras G12D mouse model and induced lung cancer formation through intranasal inhalation of Cre recombinase-expressing adenovirus (Jackson et al., 2001). This evidence concerns the gene KRAS and lung carcinoma.