These new classification proposals suggest that a diagnosis for SLE can be reached not only in patients who fulfill at least four criteria, including at least one clinical and one immunological criteria, but also in patients with biopsy-proven lupus nephritis combined with the presence of anti-nuclear antibodies (ANA) or anti-double-stranded DNA (anti-dsDNA) antibodies [11]. The gene discussed is BTG3; the disease is systemic lupus erythematosus.