LEF1 and B-cell chronic lymphocytic leukemia: Of note, three genes highlighted by the eQTL analysis, LEF1 (rs7690934), IPCEF1 (rs4869818), and DMRTA1 (rs1679013), have been previously identified as target genes of de novo active regions in CLL (Supplementary Data 5) and show higher expression in CLL compared with normal B cells12.