Furthermore, we observed increased binding affinities of the TFs previously associated with de novo active regions in CLL, that is, FOX, NFAT, and TCF/LEF family members12, at risk alleles of 16 risk loci, associated with sentinel SNPs rs11637565, rs4368253, and rs4869818, among others (Fig. 3, Supplementary Data 8). The gene discussed is HNF4A; the disease is B-cell chronic lymphocytic leukemia.