ROS1 and neoplasm: In all, 60 mg/kg of entrectinib or 10 mg/kg of lorlatinib could not induce tumor shrinkage in G2032R mutant Ba/F3-bearing mice, although lower dose of entrectinib or lorlatinib induce complete remission in the CD74-ROS1-WT-expressing Ba/F3 xenografts (Supplementary Figs. 6a, b).