Similar to the full control cohort, the top pathway represented by the rhythmic genes in the matched control cohort was Circadian Rhythm Signaling; this pathway was not significant in the schizophrenia cohort, though multiple core circadian genes do maintain rhythmicity (CIART and CRY1, for example) but with a reduced amplitude (Supplementary Data 4, Fig. 4a). Here, CIART is linked to schizophrenia.