HPN and Familial prostate cancer: Interestingly, this phenotype could not be reverted by exposure to the broad spectrum serine protease inhibitor 4-(2-Aminoethyl)-benzensulfonyl fluoride (AEBSF), but partially reverted by growth on ECM derived from prostate epithelial cells, which suggests that the microenvironment influences viability parameters of hepsin-positive prostate cancer cells19.