Other genes frequently mutated in human hematological malignancies (Ley et al., 2010; Mullighan, 2013; Yoshida et al., 2011) were detected in murine T-ALL cases, including Pten, Trp53, Ikzf1, Gata3, Setd2, U2af2, Ptpn11, Dnmt3a and Nras (Table 1). Here, SETD2 is linked to acute lymphoblastic leukemia.