Interestingly, the genomic loci for SOX10, MITF, ETS1, ETV1, ETV4, and ETV5 are associated with super-enhancers, suggesting the possibility for autoregulation; future studies will be needed to determine the roles for each of these transcription factor candidates in regulating these enhancers and super-enhancers in melanocytes and melanoma. This evidence concerns the gene ETV4 and melanoma.