Role of monoclonal antibodies targeting a single molecule (e.g., IL-13, IL-5, IgE, TNF-α) involved in the pathogenesis of EoE should be clarified, although these drugs may not break the complex self-propagating inflammatory activation responsible for perpetuation of the inflammatory response and the development of symptoms and complications. The gene discussed is IGHE; the disease is eosinophilic esophagitis.